Pulsatile drug delivery systems (PDDS) are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. It is gaining increasing attention as it offers a more sophisticated approach to the traditional sustained drug delivery i.e. a constant amount of drug released per unit time or constant blood levels. Pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. Diseases wherein PDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia. In addition, time-based colonic release can be attained when pulsatile delivery systems are properly adapted to overcome unpredictable gastric emptying and provide delay phases that would approximately match the small intestinal transit time. The current article focuses on the diseases requiring PDDS, methodologies involved for the existing systems, recent update on pulsatile drug delivery system.
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